Antifouling Surfaces for Reduction of unspecific Binding
Biofouling (bio-corrosion) is the unwelcome adsorption and adhesion of biomolecules on the surface of implants, membranes, and plastic vessels (e.g. tubes or microplates) in biological media. Once biomolecules have formed a layer on the surface, it is much easier for cells and microorganisms to attach to the surface and create so-called biofilms.
As biomolecules and cells interact non-specifically with the surface, this can lead to a higher measurement inaccuracy or a high background signal, especially when working with small sample volumes. Thus, for life science research, diagnostics, analytics, sensor technology, and medical applications, biofouling can cause a significant loss of performance.
PolyAn can functionalize polymer surfaces in a way that the unspecific adsorption of biomolecules and cell is minimized or even prevented altogether. Also the unspecific protein-adsorption of Albumin, Fibrin, Fibronectin and other “sticky proteins” can be effectively minimized.
PolyAn’s antifouling coating is covalently anchored on the base substrate. The surface modifcation is permanent, while the autofluorescence and mechanical characteristics of the base substrate are not influenced by the surface modifcation.
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PolyAn offers antifouling coatings for a wide range of plastic consumables. Our proprietary coating reduces biofouling and also cell adsorption on nearly any synthetic surface. Products include cups, 96-well microplates, microfluidic devices, and a wide range of customised products.
PolyAn is able to optimize nearly all commercially available plastic substrates according to customer specifications. Please do not hesitate to contact us, if you have any questions regarding our surface treatments.