3D-Aldehyde functionalized beads for direct coupling of biomolecules

Aldehyde groups react immediately with the NH2-terminus or other suitable functional groups of the probe to form a (covalent) bond with the surface. Thus, no activation of the bead surface is necessary prior to binding of the probe. The 3D-Aldehyde matrix has an integrated spacer structure to ensure optimal binding conditions. If necessary, the loading with Aldehyde groups can be adapted to the specific application.

Key features

  • Aldehyde groups bind to Amines, Hydrazines and Aminoalkoxyacetyl modified biomolecules
  • Suitable for one-step coupling of biomolecules, no activation of surface with Glutaraldehyde necessary
  • Different Aldehyde loadings on beads are possible
  • Wide range of sizes to choose, i.e. 100 - 500 nm submicron beads as well as 2 µm - 20 µm microspheres
  • Both transparent and fluorescence encoded beads as well as multiplex beads are available

PolyAn can functionalize all beads from our portfolio with an Aldehyde surface:

As part of our functionalization services PolyAn is now also offering the custom modification of beads with probes. Please do not hesitate to contact us (mail@poly-an.de), if you have any questions regarding our products. We are looking forward to your inquiry.

Selected publications

For a detailed description of PolyAn's 3D-Aldehyde bead surfaces please read:

Roloff, A.; Nirmalananthan-Budau, N.; Rühle, B.; Borcherding, H.; Thiele, T.; Schedler, U.; Resch-Genger, U.; Quantification of Aldehydes on Polymeric Microbead Surfaces via Catch and Release of Reporter Chromophores, Analytical Chemistry  2019, 91, 14, 8827-8834.