3D-Aldehyde functionalized beads

for direct coupling of NH²-containing molecules.

Alternative Reactions:

Aldehyde groups react immediately with NH²-groups or other suitable functional groups of the probe to form a covalent bond with the surface. Thus, no activation of the bead surface is necessary prior to binding of the probe. The 3D-Aldehyde matrix has an integrated spacer structure to ensure optimal binding conditions. If necessary, the loading with Aldehyde groups can be adapted to the specific application.

Key features

  • Aldehyde groups bind to Amines, Hydrazines, and Aminoalkoxyacetyl-modified molecules
  • No activation of surface with e.g. glutaraldehyde necessary
  • Suitable for one-step coupling of biomolecules
  • Gentle immobilization without cross-linking of biomolecules
  • Attached biomolecules can be stabilized by reducing the imines with sodium cyanoborohydride

PolyAn can functionalize all beads from our portfolio with an Aldehyde surface:

As part of our functionalization services PolyAn is now also offering the custom modification of beads with probes. Please do not hesitate to contact us (mail@poly-an.de), if you have any questions regarding our products. We are looking forward to your inquiry.

Selected publications

For a detailed description of PolyAn's 3D-Aldehyde bead surfaces please read:

  • Roloff, A. et al., `Quantification of Aldehydes on Polymeric Microbead Surfaces via Catch and Release of Reporter Chromophores´, Anal. Chem., 2019, 91, 8827. DOI: 10.1021/acs.analchem.8b05515.